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Surfaces of normal and malignant cells

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Published by Wiley in Chichester, New York .
Written in English


  • Carcinogenesis.,
  • Cancer cells.,
  • Cell membranes.,
  • Cell transformation.,
  • Cell membrane.,
  • Cell transformation, Neoplastic.,
  • Surface properties.,
  • Neoplasms.

Book details:

Edition Notes

Statementedited by Richard O. Hynes.
ContributionsHynes, Richard O.
LC ClassificationsRC268.5 .S93
The Physical Object
Paginationvi, 471 p. :
Number of Pages471
ID Numbers
Open LibraryOL4728244M
ISBN 100471997129
LC Control Number78016184

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cancer cells can arrive at a new location and survive but not proliferate to form a clinically relevant metastasis if they do not make the transition from simple survival to robust proliferation= dormancy state Help proliferation= normal cells from local bone marrow stem cells are recruited. One of the latest is Surfaces of Normal and Malignant Cells, published by John Wiley & Sons. This book, pages long and written about two years ago, costs $, which seems to me to be a lot of money. Despite these shortcomings, however, the book is worthwhile since it is ably edited by R. O. Hynes, and. Malignant transformation in vitro has several additional features which bear on its potential pathogenetic mechanisms [48,49].. i. Transformation in vitro is much more common per number of growing cells than tumor formation in vivo.. ii. Transformation occurs only in cultured cells which are grown on a solid surface, i.e., does not occur in cells which are cultured in suspension.   In a recent edition of Nature Nanotechnology, researchers report measurements of certain physical differences between the surfaces of normal and cancerous cells, suggesting a .

The regulation of oxygen (O2) levels is crucial in embryogenesis and adult life, as O2 controls a multitude of key cellular functions. Low oxygen levels (hypoxia) are relevant for tissue physiology as they are integral to adequate metabolism regulation and cell fate. Hence, the hypoxia response is of utmost importance for cell, organ and organism function and is dependent on the hypoxia Cited by: 3. Normal plasma cells are dependent on specific signals from bone marrow stem cells to regulate their differentiation, growth and localization. These same signals are required for myeloma cell growth and survival, supporting the notion that the bone marrow provides a permissive environment for disease development (Degrassi et al., ).Cited by: 2.   "Malignant cells have the ability to produce enzymes that dissolve the native tissue. This is known as invasiveness," Dr. Garcia says. Other mutations are less aggressive, forming slow-growing tumors that are not cancerous. "Benign tumors don't generally invade," Dr. Garcia says. "They usually push the normal tissue to the side.". We shall first briefly review the reactivity on normal lymphoid cells of various monoclonal antibodies we have used to study malignant tumor cell populations. We then emphasize the most important technical requirements for assessing the reactivity of MA with cell : Laurence Boumsell, Alain Bernard.

Cells from six tumorigenic lines transformed with avian sarcoma virus had highly active surfaces with many surface projections. Cells from two chemical carcinogen-transformed rat embryo lines were flat with no surface projections in subconfluent culture and rounded with only a few microvilli at high densities, but cells from a sarcoma. This property of transformed cells has been used to develop clones of malignant cells This technique has been widely used to compare the growth properties of normal and malignant cells. Cell Separation: Methods and Selected Applications, Volume 4 provides information pertinent to the design and application of methods for the separation of cells. This book covers a variety of topics, including liver cells, epidermal Langerhans cells, isolation of oval cells, clonal analysis, and the purification of polymorphonuclear leukocytes. Treatment of animals or cells in culture with carcinogenic agents is a means of studying discrete biochemical events that lead to malignant transformation. Studies of cell transformation in vitro, however, have many pitfalls. These “tissue-culture artifacts” include overgrowth of cells not characteristic of the original population of cultured cells (eg, overgrowth of fibroblasts in Cited by: 5.